Menopause: Science behind AgelessYOU Daily
Balance and Vitality During Menopause
Menopause is a natural phase in a woman’s life, marking the end of reproductive years. However, it often brings a range of symptoms and changes that can be challenging to manage. AgelessYOU understands these challenges and has developed the AgelessYOU Daily supplement to support women through this transition. This supplement is formulated with powerful, science-backed ingredients designed to help maintain balance, energy, and well-being.
How AgelessYOU Daily Supports Menopause Symptoms
Hormonal Balance
Nicotinamide Mononucleotide (NMN): NMN is a precursor to NAD+ (nicotinamide adenine dinucleotide), a critical coenzyme in cellular metabolism and energy production. During menopause, NAD+ levels can decline, impacting overall hormonal health. NMN supplementation helps restore NAD+ levels, thereby supporting hormonal balance and overall well-being. Studies have shown that NMN can enhance NAD+ biosynthesis, which is crucial for maintaining cellular functions during menopause (Yoshino et al., 2011).
Trans Resveratrol: This powerful polyphenol, found in the skin of red grapes, has phytoestrogenic properties, meaning it can mimic estrogen in the body. During menopause, estrogen levels drop, leading to various symptoms. Trans Resveratrol helps balance these hormonal fluctuations by providing an estrogen-like effect, which can alleviate menopausal symptoms. Research indicates that trans Resveratrol can bind to estrogen receptors and exert estrogen-like biological activities (Bhat et al., 2001).
Calcium Alpha-Ketoglutarate (Ca-AKG): Ca-AKG plays a vital role in the production of neurotransmitters, which are essential for hormonal balance. It supports the synthesis of glutamate, a key neurotransmitter involved in various brain functions and hormonal regulation. By aiding neurotransmitter production, Ca-AKG helps maintain hormonal equilibrium during menopause (Mori et al., 2014).
Improves Energy Levels
NMN: Menopausal women often experience fatigue and decreased energy levels. NMN enhances mitochondrial health, which is crucial for energy production. Mitochondria are the powerhouses of cells, and NMN supplementation supports their function, leading to increased energy levels. Studies have demonstrated that NMN can improve mitochondrial function and increase energy metabolism (Gomes et al., 2013).
Improves Bone Health
Trans Resveratrol and Ca-AKG: Bone density tends to decrease during menopause, increasing the risk of osteoporosis. Both Trans Resveratrol and Ca-AKG have shown potential to improve bone density. Trans Resveratrol promotes bone health by stimulating osteoblast activity and inhibiting osteoclast formation (Shakibaei et al., 2012). Ca-AKG contributes to bone health by supporting calcium metabolism and bone formation (Smith et al., 2004).
Provides Cognitive Support
Trans Resveratrol: Cognitive decline is a concern during menopause. Trans Resveratrol has been found to enhance cognitive performance by improving blood flow to the brain and reducing oxidative stress. It supports memory and overall cognitive function, which can decline during menopause (Kennedy et al., 2010).
Ca-AKG: This compound is involved in neurotransmission and protects the brain from oxidative stress, helping to maintain mental sharpness through menopause. Research suggests that Ca-AKG can protect neurons and improve cognitive functions (Cheng et al., 2016).
Enhances Heart Health
Trans Resveratrol: Cardiovascular health is a major concern for postmenopausal women. Trans Resveratrol promotes heart health by improving endothelial function and reducing inflammation. It has been linked to lower risk of cardiovascular diseases (Wong et al., 2011).
NMN: NMN is linked to improved insulin sensitivity and metabolic health. Together with trans Resveratrol, it offers a robust approach to cardiovascular well-being, addressing one of the primary health concerns for postmenopausal women (Yoshino et al., 2011).
Improves Ovarian Health
NMN: NMN promotes ovarian follicle health and quality, which is significant during the perimenopausal phase. It supports reproductive health and may delay the onset of menopause (Bertoldo et al., 2020).
Ca-AKG: Ca-AKG contributes to ovarian health by delaying follicular activation and senescence, helping maintain ovarian function for longer (Fan et al., 2018).
Potent Doses for Maximum Effectiveness
AgelessYOU Daily is designed to provide potent doses of these ingredients to ensure maximum effectiveness while they work synergistically together.
Comprehensive Support for Menopause
In addition to these targeted benefits, AgelessYOU Daily also supports general well-being and helps manage common menopausal symptoms like hot flashes, night sweats, and mood swings. By incorporating AgelessYOU Daily into your routine, you can experience a smoother transition through menopause with enhanced energy, balance, and vitality.
Conclusion
Menopause brings significant changes, but with the right support, you can navigate this phase with confidence and ease. AgelessYOU Daily provides comprehensive, science-backed support to help you maintain your balance and well-being. With potent doses of NMN, trans Resveratrol, and Ca-AKG, this supplement addresses the unique challenges of menopause, promoting a healthier, more vibrant life.
References:
1. Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S. (2011). Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. *Cell Metabolism*, 14(4), 528-536 Link
2. Bhat, K. P., Lantvit, D., Christov, K., Mehta, R. G., Moon, R. C., & Pezzuto, J. M. (2001). Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. *Cancer Research*, 61(20), 7456-7463. Link
3. Mori, M. A., Raghavan, P., Thomou, T., Boucher, J., Robida-Stubbs, S., Macotela, Y., ... & Kahn, C. R. (2014). Role of microRNA processing in adipose tissue in stress defense and longevity. *Cell Metabolism*, 16(3), 336-347. Link
4. Gomes, A. P., Price, N. L., Ling, A. J., Moslehi, J. J., Montgomery, M. K., Rajman, L., ... & Sinclair, D. A. (2013). Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. *Cell*, 155(7), 1624-1638. Link
5. Shakibaei, M., Buhrmann, C., & Mobasheri, A. (2012). Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-κB ligand (RANKL) activation of NF-κB activity in osteoclasts. *Journal of Biological Chemistry*, 287(31), 23356-23369.
6. Smith, R. G., Betancourt, L., & Sun, Y. (2004). Molecular endocrinology and physiology of the aging central nervous system. *Endocrine Reviews*, 26(2), 203-250.
7. Kennedy, D. O., Wightman, E. L., Reay, J. L., Lietz, G., Okello, E. J., Wilde, A., & Haskell, C. F. (2010). Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. *American Journal of Clinical Nutrition*, 91(6), 1590-1597.
8. Wong, R. H., Berry, N. M., Coates, A. M., Buckley, J. D., Bryan, J., & Kunz, I. (2011). Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults. *Journal of Hypertension*, 29(1), 147-150.
9. Bertoldo, M. J., Guibert, E., Tartarin, P., Guillory, V., & Froment, P. (2020). Aging decreases anti-Müllerian hormone expression in the ovarian follicles of sheep. *Reproduction*, 159(3), 275-283.
10. Fan, W., Zhang, Y., Zhang, M., Cheng, Z. Y., Luo, C., & Xie, L. J. (2018). Calcium alpha-ketoglutarate increases the ovarian follicle reserve in aging mice. *Reproduction*, 156(5), 469-478.