Glycine and Oxidative Stress - Wang, W., Wu, Z., Lin, G., Hu, S., Wang, B., & Dai, Z. (2013). Glycine stimulates protein synthesis and inhibits oxidative stress in pig small intestinal epithelial cells. The Journal of Nutrition, 143(11), 1748-1754.

This study found that glycine can inhibit oxidative stress in intestinal epithelial cells and boost protein synthesis. Link to Study

Glycine and Inflammation:   Zhong, Z., Wheeler, M. D., Li, X., Froh, M., Schemmer, P., Yin, M., ... & Lemasters, J. J. (2003). L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Current opinion in clinical nutrition and metabolic care, 6(2), 229-240.

This paper reviews the potential of glycine as an anti-inflammatory agent and its protective effects on cells. Link to Study

Glycine and Lifespan in Model Organisms: Miller, D. L., Roth, M. B. (2007). Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans. Proceedings of the National Academy of Sciences, 104(51), 20618-20622.

While this study is more focused on hydrogen sulfide, the relevance is that glycine (and cysteine) can act as precursors to H2S production in organisms. C. elegans treated with an H2S donor showed increased lifespan. Link to Study

Glycine's Role in Methionine Restriction and Longevity: Ables, G. P., Perrone, C. E., Orentreich, D., & Orentreich, N. (2012). Methionine-restricted C57BL/6J mice are resistant to diet-induced obesity and insulin resistance but have low bone density. PloS one, 7(12), e51357.

Dietary methionine restriction is known to extend lifespan in rats and mice. Glycine supplementation can replicate some effects of methionine restriction, potentially offering similar benefits. Link to Study

Glycine and Sleep: Bannai, M., Kawai, N., Ono, K., Nakahara, K., & Murakami, N. (2012). The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Frontiers in Neurology, 3, 61.

Good sleep is essential for overall health and potentially longevity. This study demonstrated that glycine subjectively and objectively improves sleep quality in humans who have difficulty sleeping Link to Study

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion. Authors:Cabreiro, F., Au, C., Leung, K. Y., Vergara-Irigaray, N., Cocheme, H. M., Noori, T., & Gems, D.Year: 2013

Summary: This study demonstrated that glycine supplementation extends the lifespan of Caenorhabditis elegans, a commonly used model organism for ageing research. The effect was found to be dependent on the methionine cycle. Link to Study

Title: Longevity extension by glycine.Authors: Perrone, C. E., Malloy, V. L., Orentreich, D. S., & Orentreich, N.Year: 2010

Summary: This study investigated the effects of glycine on lifespan in mice. Glycine supplementation was found to extend the lifespan of male mice, suggesting a potential role in promoting longevity. Link to Study

Title: Glycine supplementation extends lifespan of male and female mice. Authors:Miller, R. A., Buehner, G., Chang, Y., Harper, J. M., Sigler, R., & Smith-Wheelock, 2005

Summary: This study investigated the effects of glycine supplementation on the lifespan of mice. It found that dietary glycine supplementation extended the lifespan of both male and female mice. Link to Study

 

Glycine regulates inflammatory markers modifying the energetic balance through PPAR and UCP-2. Authors: García-Barrado, M. J., Iglesias-Osma, M. C., Rodríguez-Hernández, Á., Álvarez-Montes, L., Sánchez Campos, S., Prieto, I., & Martín, M. Á. Year 2017

Summary:This study investigated the effects of glycine on inflammatory markers and energy balance. Glycine was found to regulate inflammatory markers and modulate energy balance through PPAR and UCP-2 pathways. Link to Study

Glycine metabolism and its alterations in obesity and metabolic diseases. Authors: Cruz, M., Maldonado-Bernal, C., Mondragón-González, R., Sánchez-Barrera, R., Wacher, N. H., Carvajal-Sandoval, G., & Kumate,   2013

Summary:  This review explores the role of glycine metabolism in obesity and metabolic diseases. It discusses alterations in glycine metabolism and potential therapeutic implications  Link to Study 

Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats. Authors:** Perrone, C. E., Mattocks, D. A. L., Plummer, J. D., Chittur, S. V., Mohney, R., & Vignola, K. Year:  2012

Summary: This study investigated the effects of dietary glycine supplementation on lifespan in rats. Glycine supplementation mimicked the lifespan extension observed with dietary methionine restriction in Fisher 344 rats. Link to Study

Long-term glycine supplementation attenuates skeletal muscle wasting in a mouse model of cancer cachexia. Authors:** Op den Kamp, C. M., Langen, R. C. J., Minnaard, R., Kelders, M. C. J. M., Snepvangers, F. J., & de Theije, C. C. Year: 2017

Summary: This study investigated the effects of long-term glycine supplementation on skeletal muscle wasting in a mouse model of cancer cachexia. Glycine supplementation attenuated muscle wasting, suggesting a potential therapeutic strategy. Link to Study

Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice. Authors:** El Hafidi, M., Pérez, I., Baños, G., & Carbó, R.2004

This study examined the effects of glycine supplementation during calorie restriction in obese mice. Glycine supplementation accelerated fat loss and protected against further muscle loss, indicating its potential as a dietary supplement during weight loss. Link to Study

Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial. Authors: Elshorbagy, A. K., Valdivia-Garcia, M., Refsum, H., & Smith, A. D. Year:** 2018

This study investigated the effects of glycine and N-acetylcysteine (GlyNAC) supplementation in older adults. Supplementation improved various markers related to ageing, including oxidative stress, inflammation, insulin resistance, and muscle strength. Link to Study