Riche, D. M., Riche, K. D., Blackshear, C. T., McEwen, C. L., Sherman, J. J., Wofford, M. R., & Griswold, M. E. (2014): Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial. *Evidence-Based Complementary and Alternative Medicine, 2014

This trial evaluated the effect of pterostilbene on metabolic parameters in individuals with a higher risk for type 2 diabetes. In terms of safety, the participants taking pterostilbene showed no significant difference in liver, kidney, or hematological markers when compared to the placebo group. Some participants in the pterostilbene groups did experience an increase in total cholesterol and LDL levels, so it's essential to consider these factors when assessing its safety profile Link to  Study

Riche, D. M., Riche, K. D., East, H. E., Barrett, E. K., & May, W. L. (2017). Impact of pterostilbene on metabolic parameters in humans. University of Mississippi Medical Center, 4(1), 8.

   - This study investigated the effects of pterostilbene supplementation on metabolic parameters and body composition in adults. The results indicated beneficial impacts on body composition, but, as with the previously mentioned studies, there were changes in cholesterol levels. Link to Study 

 Kapetanovic, I. M., Muzzio, M., Huang, Z., Thompson, T. N., & McCormick, D. L. (2011): Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Cancer Chemotherapy and Pharmacology, 68(3), 593-601

  This study, although conducted in rats, provides insights relevant to humans about the pharmacokinetics and metabolism of pterostilbene compared to resveratrol. It demonstrated that pterostilbene had higher oral availability and longer elimination half-life than resveratrol. Link to Study

 Chang, J., Rimando, A., Pallas, M., Camins, A., Porquet, D., Reeves, J., ... & Shukitt-Hale, B. (2012). Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in ageing and Alzheimer's disease. Neurobiology of ageing, 33(9), 2062-2071

In this study, rats were supplemented with pterostilbene to study its potential neuroprotective effects against ageing and Alzheimer's disease. Pterostilbene was found to be effective in modulating cognitive function and may hold potential as a significant neuromodulator in ageing. Link to study

Joseph, J. A., Fisher, D. R., Cheng, V., Rimando, A. M., & Shukitt-Hale, B. (2008). Cellular and behavioural effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of ageing. Journal of Agricultural and Food Chemistry, 56(22), 10544-10551.

 The study found that pterostilbene was effective in reversing cognitive decline in aged rats and might be a potent compound in preventing age-related deficits in memory. Link to study

Dellinger, R. W., Garcia, A. M., Meyskens, F. L. (2014). Differences in the glucuronidation of resveratrol and pterostilbene: altered enzyme specificity and potential gender differences. Drug metabolism, disposition & the biological fate of chemicals, 42(2), 353-359

 The study discusses the metabolism of pterostilbene and suggests that its modified chemical structure may confer improved bioavailability and metabolic stability compared to resveratrol. Link to Study

Rimando, A. M., Cuendet, M., Desmarchelier, C., Mehta, R. G., Pezzuto, J. M., & Duke, S. O. (2002). Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. *Journal of Agricultural and Food Chemistry, 50(12), 3453-3457.

This research suggests that pterostilbene can suppress inflammation and inhibit cancer cell growth, possibly impacting cellular senescence. Link to study

Pari, L., & Satheesh, M. A. (2008). Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin-and nicotinamide-induced diabetic rats. Life sciences, 83(3-4), 110-115.

 This study demonstrated that pterostilbene can modulate enzymes responsible for glucose metabolism in diabetic rats, suggesting an influence on insulin sensitivity and glucose uptake. Link to Study