Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Ageing Mice
This study explored the effect of CaAKG supplementation in mice, indicating it can extend lifespan and healthspan while reducing frailty and morbidity.
https://pubmed.ncbi.nlm.nih.gov/32877690/

Alpha-Ketoglutarate, the Metabolite that Regulates Ageing in Mice
This research found that CaAKG positively influences survival rates and health indicators in aged mice, supporting its potential anti-ageing effects.
https://pubmed.ncbi.nlm.nih.gov/32877690/

Alpha-Ketoglutarate Reduces Ageing
This article discusses a trial with 42 healthy individuals using an AKG-based dietary supplement, which showed promising results in reducing biological age based on epigenetic markers.
https://www.lifespan.io/news/alpha-ketoglutarate-reduces-aging/

Alpha-ketoglutarate as a potent regulator for lifespan and healthspan
This paper reviews various studies highlighting AKG's role in promoting health and extending life, reinforcing its importance in metabolic pathways and potential in ageing intervention.
https://pubmed.ncbi.nlm.nih.gov/34534645/